The NRT-NMJ targets a specific DNA replication enzyme. Recently, we found that a certain DNA replication enzyme was increased in most solid tumors by analysis of large cohort genomic datasets. NEORNAT inc., has verified that this enzyme plays a pivotal role in the development of cancer. Therefore, blocking this enzyme suppressed the expression of DNA methyltransferases, resulting in there-expression of tumor suppressor genes in cancer cells. NRT-NMJ is a pipeline that increases the transcription of tumor suppressor genes by inhibiting the expression of this DNA methyltransferases with siRNAs that target specific DNA replication enzyme.